Chlordiazepoxide and clidinium

klor-dye-az-e-POX-ide hye-droe-KLOR-ide, kli-DIN-ee-um BROE-mide

Commonly used brand name(s)

In the U.S.

• Librax

Available Dosage Forms:

• Capsule

Therapeutic Class: Antimuscarinic Combination

Pharmacologic Class: Chlordiazepoxide

Uses For chlordiazepoxide and clidinium

Chlordiazepoxide and clidinium combination is used in combination with other therapies to treat stomach or bowel problems such as peptic ulcers, irritable bowel syndrome (IBS), and enterocolitis (inflammation of the colon and small intestines).

Chlordiazepoxide is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

Clidinium is an anticholinergic agent. It reduces stomach acid and decreases bowel spasms.

chlordiazepoxide and clidinium is available only with your doctor's prescription.

Before Using chlordiazepoxide and clidinium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For chlordiazepoxide and clidinium, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to chlordiazepoxide and clidinium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of chlordiazepoxide and clidinium combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlordiazepoxide and clidinium combination in the elderly. However, severe drowsiness, confusion, clumsiness, or unsteadiness are more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of chlordiazepoxide and clidinium combination. Elderly patients may require a lower dose to help reduce unwanted effects.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking chlordiazepoxide and clidinium, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using chlordiazepoxide and clidinium with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium

Using chlordiazepoxide and clidinium with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amobarbital


• Anileridine


• Aprobarbital


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlorzoxazone


• Codeine


• Dantrolene


• Ethchlorvynol


• Fentanyl


• Fospropofol


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Primidone


• Propoxyphene


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Thiopental


• Zolpidem

Using chlordiazepoxide and clidinium with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ketoconazole


• St John's Wort


• Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using chlordiazepoxide and clidinium with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use chlordiazepoxide and clidinium, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of chlordiazepoxide and clidinium. Make sure you tell your doctor if you have any other medical problems, especially:

• Drug or alcohol abuse or dependence or


• Mental illness, history of or


• Weakened physical condition—Use with caution. May make these conditions worse.

• Enlarged prostate or


• Glaucoma or


• Urinary bladder neck blockage—Should not be used in patients with these conditions.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of chlordiazepoxide and clidinium

Take chlordiazepoxide and clidinium exactly as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take chlordiazepoxide and clidinium before meals and at bedtime.

Dosing

The dose of chlordiazepoxide and clidinium will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of chlordiazepoxide and clidinium. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For the treatment of peptic ulcer, IBS, or enterocolitis:
    
    • Adults—One or two capsules three or four times a day. Your doctor may adjust your dose as needed and tolerated.
    
    
    • Older adults—Two capsules per day. Your doctor may adjust your dose as needed and tolerated.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of chlordiazepoxide and clidinium, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using chlordiazepoxide and clidinium

It is very important that your doctor check your progress at regular visits to make sure chlordiazepoxide and clidinium is working properly. Blood tests may be needed to check for unwanted effects.

Using chlordiazepoxide and clidinium while you are pregnant may cause serious unwanted effects in your newborn baby. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using chlordiazepoxide and clidinium.

chlordiazepoxide and clidinium may cause some people, especially elderly patients, to become drowsy, dizzy, lightheaded, clumsy or unsteady, or less alert than they are normally. Make sure you know how you react to chlordiazepoxide and clidinium before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

chlordiazepoxide and clidinium will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or seizure medicines; muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking chlordiazepoxide and clidinium. Check with your doctor before taking any of the above while you are using chlordiazepoxide and clidinium.

Call your doctor if you experience dark-colored urine or pale stools; nausea, vomiting, loss of appetite, or pain in your upper stomach; or yellowing of the skin or eyes. These could be signs of a serious liver problem. .

Call your doctor if you have unusual bleeding or bruising or weakness. These could be signs of a serious blood problem called agranulocytosis. .

If you develop any unusual and strange thoughts or behavior while you are taking chlordiazepoxide, be sure to discuss it with your doctor. Some changes that have occurred in people taking chlordiazepoxide and clidinium are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, suicidal thoughts, and unusual excitement, nervousness, or irritability.

Do not stop taking it without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), stomach or muscle cramps, tremors, or unusual behavior.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

chlordiazepoxide and clidinium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach pain


• chills


• clay-colored stools


• confusion


• cough or hoarseness


• dark urine


• difficulty with speaking


• dizziness


• drooling


• drowsiness


• fever


• fever with or without chills


• general feeling of tiredness or weakness


• headache


• itching


• loss of appetite


• loss of balance control


• lower back or side pain


• muscle trembling, jerking, or stiffness


• nausea


• painful or difficult urination


• pale skin


• rash


• restlessness


• shakiness and unsteady walk


• shuffling walk


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• stiffness of the limbs


• swelling


• twisting movements of the body


• uncontrolled movements, especially of the face, neck, and back


• unpleasant breath odor


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual bruising or bleeding


• unusual tiredness or weakness


• vomiting of blood


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Blurred vision


• change in consciousness


• difficulty having a bowel movement (stool)


• dry mouth


• lack of coordination


• loss of consciousness


• sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Inability to have or keep an erection


• increase or loss in sexual ability, desire, drive, or performance


• increased or decreased interest in sexual intercourse


• menstrual changes


• skin blisters

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: chlordiazepoxide and clidinium side effects (in more detail)

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More chlordiazepoxide and clidinium resources

• Chlordiazepoxide and clidinium Side Effects (in more detail)
• Chlordiazepoxide and clidinium Dosage
• Chlordiazepoxide and clidinium Use in Pregnancy & Breastfeeding
• Drug Images
• Chlordiazepoxide and clidinium Drug Interactions
• Chlordiazepoxide and clidinium Support Group
• 14 Reviews for Chlordiazepoxide and clidinium - Add your own review/rating

Compare chlordiazepoxide and clidinium with other medications

• Enterocolitis
• Irritable Bowel Syndrome
• Peptic Ulcer